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21c Hotel

Hotels Louisville
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The 21c is a chic, boutique hotel and contemporary art museum, nestled into historic downtown Louisville. The galleries are open 24-7 to the public, and the restaurant, Proof on Main, is a must-stop even if you’re not staying at the hotel (but you should). 21c Hotel 700 W Main St., Louisville, KY 40202; (502) 217-6300

Seelbach Hilton

Hotels Louisville
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This downtown Louisville hotel combines 1920’s glamour (F. Scott Fitzgerald used the location as a backdrop for Tom and Daisy’s wedding in the Great Gatsby) with modern luxury. Enjoy the fine dining at its five diamond restaurant, The Oakroom. Seelbach Hilton 500 S 4th Street, Louisville, KY 40202; (502) 585-3200